4-octyl itaconate

4-Octyl Itaconate, a cell-permeable derivative of Itaconate, is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 and inhibits phosphorylation of STING.

4-Octyl itaconate-Bn-S-NH2 (Compound 8b) functions as a vasorelaxant. It releases H₂S slowly and steadily, helping to reduce oxidative stress through antioxidant reactions that depend on Nrf2 activation. It also inhibits the generation of intracellular ROS and cytotoxicity caused by H₂O₂ damage and activates the potassium channel. This compound is applicable in hypertension research.

4-Octyl itaconate-13C5-1 is the 13C-labeled version of 4-Octyl itaconate (T4580). Itaconate serves as an anti-inflammatory metabolite that activates Nrf2 through the alkylation of KEAP1.