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AICAR (Acadesine) is an AMPK activator. AICAR has the functions of metabolic regulation, muscle function regulation, anti-cancer effect, neuroprotection and anti-aging.

AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.

AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes.

AICAR-13C2,15N is the isotopically labeled form of AICAR (T1477) with carbon-13 and nitrogen-15. AICAR (T1477) (Acadesine) acts as an adenosine analog and an AMPK activator, playing a role in glucose and lipid metabolism regulation, while inhibiting pro-inflammatory cytokines and iNOS production. Additionally, AICAR (T1477) functions as an inhibitor of autophagy, YAP, and mitochondrial autophagy.