2-hydroxyglutaric acid disodium

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).

D-α-Hydroxyglutaric acid disodium [Disodium (R)-2-Hydroxyglutarate] is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with a Ki of 0.628 mM.

D-α-Hydroxyglutaric acid-D5 disodium isodium (Disodium (R)-2-hydroxyglutarate-D5) is the deuterated version of D-α-Hydroxyglutaric acid disodium. This compound is a major metabolite that accumulates in the neurometabolic disorder D-2-hydroxyglutaric aciduria. As a weak competitive antagonist of α-ketoglutaric acid (α-KG), D-α-Hydroxyglutaric acid disodium (T6820) inhibits various α-KG-dependent dioxygenases with a Ki of 10.87 mM. It also promotes the production of reactive oxygen species (ROS), binds to and inhibits ATP synthase, and suppresses mTOR signaling.

DL-alpha-Hydroxyglutaric acid disodium salt is an alpha-ketoglutarate (α-KG) antagonist that inhibits a variety of α-KG-dependent dioxygenases.

DL-α-Hydroxyglutaric acid-D4 disodium salt is a deuterated compound of DL-α-Hydroxyglutaric acid disodium salt. DL-α-Hydroxyglutaric acid disodium salt (T21665) has a CAS number of 40951-21-1. DL-α-Hydroxyglutaric acid disodium salt (T21665) is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuran carboxylic acid, which is overproduced in human neurometabolic disease D-α -hydroxyglutaric uria.

α-Hydroxyglutaric acid-D4 disodium is the deuterated form of α-Hydroxyglutaric acid disodium (T21665). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium represents the α-hydroxy acid form of glutaric acid. It acts as a competitive inhibitor for several α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine (5mC) hydroxylases.