2'-deoxyadenosine-5'-triphosphate

2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-triphosphate (dATP) is a substrate for DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate (dATP) is an inhibitor of RNA through an inactive alpha4beta4 quaternary structure. Deoxyadenosine-5'-triphosphate inhibits RNA through the inactive α4beta4 quaternary structure.2'-Deoxyadenosine-5'-triphosphate has been associated with cardiomyocyte growth.

2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide substrate for DNA polymerase, essential for DNA synthesis and replication in cells.

2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Key steps in nucleotide biosynthesis are regulated by feedback inhibitionBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.DNA is replicated by polymerases that take instructions from templatesBiochemistry(2002) 3.Cadwell, R.C., and Joyce, G.F.Randomization of genes by PCR mutagenesisPCR Methods Appl.2(1)28-33(1992) 4.Steffens, D.L., Jang, G.Y., Sutter, S.L., et al.An infrared fluorescent dATP for labeling DNAGenome Res.5(4)393-399(1995) 5.Flinn, A.M., and Gennery, A.R.Adenosine deaminase deficiency: A reviewOrphanet J. Rare Dis.13(1)65(2018)

2'-Deoxyadenosine-5'-triphosphate-D14 dilithium is a deuterium-labeled version of 2'-Deoxyadenosine-5'-triphosphate. This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (T36667) (dATP), is employed in cells for DNA synthesis or replication and acts as a substrate for DNA polymerase.

2'-Deoxyadenosine-5'-triphosphate-15N5 dilithium is a version of 2'-Deoxyadenosine-5'-triphosphate dilithium (T36667) that is labeled with nitrogen-15 (15N). This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), plays a crucial role in cellular processes as it is utilized in DNA synthesis or replication. Additionally, 2'-Deoxyadenosine-5'-triphosphate (dATP) serves as a substrate for DNA polymerase.

2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 dilithium is the isotope-labeled form of 2'-Deoxyadenosine-5'-triphosphate dilithium (T36667). This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), plays a critical role in cells for DNA synthesis and replication, serving as a substrate for DNA polymerases.

2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium is a 13C-labeled form of 2'-Deoxyadenosine-5'-triphosphate dilithium (T36667). This nucleotide, 2'-Deoxyadenosine-5'-triphosphate (dATP), is utilized in cellular processes for DNA synthesis or replication and serves as a substrate for DNA polymerase.

7-Deaza-2'-deoxyadenosine-5'-O-triphosphate (C7-dATP) tetrasodium is a derivative of ATP. ATP (Adenosine 5'-triphosphate) is a central component in energy storage and metabolism within the body.

2'-Deoxytubercidin 5'-triphosphate (C7dATP) sodium is a deoxyadenosine triphosphate (dATP) analog designed to reduce electrophoretic mobility anomalies caused by compression at G or A residues, thereby enhancing the quality of DNA sequencing data.

2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate) is an adenosine derivative that functions as a weak competitive inhibitor of ATP, with a K i value of 2.3 mM, and is used in nucleic acid labeling.

2'-Deoxyadenosine-5'-monophosphate (D-AMP) is a nucleoside comprised of adenine attached to a ribose (ribofuranose) moiety via a -N9-glycosidic bond. Deoxyadenosine monophosphate is a derivative of the common nucleic acid ATP, or adenosine triphosphate, in which the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been removed (hence the deoxy- part of the name). Additionally, the monophosphate of the name indicates that two of the phosphoryl groups of GTP have been removed, most likely by hydrolysis. Deoxyadenosine monophosphate is abbreviated dAMP.

2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate (ε-dATP), a fluorescent derivative of 2'-deoxyadenosine-5'-O-triphosphate (dATP), promotes sister chromatid exchange in stimulated primary mouse spleen T- and B lymphocytes with LPS or concanavalin A at concentrations of 50 to 150 µM. Utilized in ambiguous base pairing investigations within vinyl chloride-induced mutagenesis research, ε-dATP, along with its related compound ε-ATP—which exhibits an emission peak at 415 nm after being excited at 300 nm—contributes to understanding genetic alterations mechanisms.

2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate) tetrasodium, an adenosine derivative, functions as a weak competitive inhibitor of ATP with a Ki value of 2.3 mM. It is also utilized for nucleic acid labeling.

2'-Deoxy-3'-O-valeryladenosine-5'-O-triphosphate (triethylammonium) is a derivative of 2'-Deoxyadenosine-5'-triphosphate. It is utilized within cells for DNA synthesis, sequencing, and labeling studies.

3'-O-Acetyl-dATP is an acetylated derivative of dATP, utilized as a chain terminator in DNA synthesis during Sanger sequencing.

3'-O-Acetyl-2'-deoxyadenosine-5'-O-triphosphate (sodium) (3'-O-Acetyl-dATP (sodium)) is an acetylated derivative of the purine nucleotide 2'-deoxyadenosine-5'-triphosphate. It is utilized as a chain-terminating agent in DNA synthesis during Sanger sequencing.

2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with significant biological activity, serving as a substrate for various polymerases, such as DNA polymerase and reverse transcriptase. It plays a crucial role in both DNA synthesis and reverse transcription and is extensively used in vitro for molecular biology research.