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2',3'-cgamp sodium

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2',3'-cGAMP sodium
2'-3'-cyclic GMP-AMP sodium
T10065L2734858-36-5In house
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
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2',3'-cGAMP
Cyclic GMP-AMP, 2'-3'-Cyclic GMP-AMP
T100651441190-66-4
2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.
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