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β-Apo-13-carotenone, a naturally occurring apocarotenoid, functions as an antagonist of the retinoid X receptor (RXR). β-Apo-13-carotenone inhibits transactivation of RXRα but does not interfere with coactivator binding to the receptor in the manner observed for the known antagonist UVI3003. β-Apo-13-carotenone induces the formation of a transcriptionally silent RXR tetramer. β-Apo-13-carotenone is therefore relevant for mechanistic investigations involving nuclear receptor signaling, transcriptional regulation, and retinoid-associated cellular processes.

β-Apo-13-carotenone-D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone (T13431) is an antagonist of RXRα.