1616493-44-7

Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.

Tucidinostat-D4 is the deuterated form of Tucidinostat. Tucidinostat (T4481) is an effective, orally bioavailable inhibitor of HDAC class I HDAC1/2/3 and class IIb HDAC10, with IC50 values of 95, 160, 67, and 78 nM, respectively.

HDAC-IN-7, an analogue of Tucidinostat (Chidamide), is a HDAC inhibitor. HDAC-IN-7 inhibits acetylation of histone protein H3 and induces apoptosis in human colon cancer cell lines[1].