100286-90-6

Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.

Irinotecan-D10 is the deuterated form of Irinotecan (T6228) ( (+)-Irinotecan), which acts as an inhibitor of topoisomerase I and is utilized in research related to colon and rectal cancers.

Irinotecan-D10 hydrochloride is a deuterated compound of Irinotecan Hydrochloride. Irinotecan Hydrochloride (T0486L) has a CAS number of 100286-90-6. Irinotecan Hydrochloride (T0486L) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Irinotecan (Standard) is a reference standard for research and analysis in studies involving Irinotecan. Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.

Irinotecan-D10 (Standard) is a reference standard of Irinotecan-D10 intended for quantitative analysis, quality control, and related biochemical research applications. Irinotecan-d10 is the deuterated form of Irinotecan ((+)-Irinotecan), which acts as an inhibitor of topoisomerase I and is utilized in research related to colon and rectal cancers.

Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.

Irinotecan-[13C6] (Standard) is a reference standard of Irinotecan-[13C6] intended for quantitative analysis, quality control, and related biochemical research applications.