β3-ar in cells

Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist that promotes cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR (EC50: 22 nM). It is used to treat overactive bladder and irritable bowel syndrome.

D-Mannitol-d4 (Mannitol-d4) is the deuterium-labeled variant of D-Mannitol. D-Mannitol (Mannitol) is a resistant sugar with oral activity, widely utilized in the food and pharmaceutical industries. It facilitates calcium and magnesium absorption and retention via cecal fermentation and reduces tissue edema as an osmotic diuretic. Additionally, D-Mannitol can enhance brown fat formation, improve insulin action, lower blood glucose levels, and promote the conversion of white adipose cells to brown via β3-adrenergic receptor (β3-AR), PGC1α, and PKA pathways. It is also used to maintain osmotic pressure between plant protoplasts and culture media, protecting cells when the cell wall is weakened or removed.