β lactamase in 4

β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.

Metallo-β-lactamase-IN-4 (compound 40) is a potent inhibitor of metallo-β-lactamases (MBL) with IC50 values of 0.5 μM for VIM-1, 2.1 μM for NDM-1, and 3.3 μM for IMP-7, respectively [1].

IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.

β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) is a β-Lactamase inhibitor and targets the infection of Neisseria gonorrhoeae.

Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamase (MBL) inhibitor with IC50 values of 0.1 μM for VIM-1, 1.3 μM for NDM-1, and 5.0 μM for IMP-7, respectively [1].

NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.

β-Lactamase-IN-7 (compound 14) is a potent inhibitor of VIM-type metallo-β-lactamase, effectively inhibiting Klebsiella pneumoniae with Ki values of 1.26 μM for VIM-1 and 0.54 μM for VIM-4 [1].

MBL-IN-3 (compound 72922413), a potent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) with an IC50 value of 54±4 μM, effectively reduces the minimum inhibitory concentrations (MICs) of Meropenem against clinical isolates of E. coli and K. pneumoniae that express NDM-1. This compound is utilized in studies focused on antibiotic sensitizer research [1].