α-globin

3-(3,4-Dimethoxyphenyl)propanoic acid (3,4-Dimethoxyhydrocinnamic acid) is an orally active short-chain fatty acid (SCFAs) that promotes γ-globin gene expression and erythropoiesis in vivo, making it useful in treating beta hemoglobinopathies and other anemias.

Iptacopan hydrochloride (LNP023 hydrochloride) is a small-molecule inhibitor and a complement factor B inhibitor (IC50 = 10 nM, KD = 7.9 nM) with high selectivity, oral activity, and cell permeability, used for the treatment of complement-mediated diseases including paroxysmal nocturnal hemoglobinuria, IgA nephropathy, and C3 glomerulopathy.

Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).

Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.

Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.

Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM

TN1 is a potent inducer of fetal hemoglobin (HbF).

Haptoglobin, Phenotype 2-2 is a plasma protein that binds hemoglobin (Hb) to remove free hemoglobin and possesses antioxidant activity. It can be utilized in research related to kidney failure and cardiovascular diseases associated with diabetes.

RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).

FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.

Pepstatin (Pepsin Inhibitor S 735A) is an aspartate protease inhibitor that also inhibits HIV protease activity with specific and oral activity. Pepstatin inhibits autophagy.

Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.

Hemoglobin, which is the primary cause of sickle cell disease (SCD) abnormalities, can be utilized to determine fetal hemoglobin through time-resolved immunofluorescence assay [1].

Anti-Haptoglobin Antibody is a humanized monoclonal antibody expressed in CHO cells targeting Haptoglobin (HP). This product, featuring a huIgG1 heavy chain and a hukappa light chain, has a predicted molecular weight of 150 kDa. It binds specifically to Haptoglobin with high affinity, blocking its interaction with free hemoglobin (Hb) or damage-associated molecular patterns (DAMPs, such as HMGB1). By interfering with HP-mediated ligand clearance mechanisms (e.g., the CD163 pathway), the antibody inhibits its anti-inflammatory or immunomodulatory functions. It serves as an important pharmacological tool for researching hemolytic diseases, acute phase responses, and the tumor immune microenvironment.

Vasicinol (6-Hydroxypeganine), a pyrroloquinazoline alkaloid isolated from Adhatoda vasica (L.), Nees, is a sucrase inhibitor that inhibits the sucrose hydrolyzing activity of rat intestinal α-glucosidase, with a Ki value of 183 μM.Vasicinol is a HbF inducer. Vasicinol is an HbF inducer and can be used to study metabolic disorders and diabetes.

Hemoglobin (64-76) is a polypeptide molecule with the sequence GKKVITAFNEGLK.

Myoglobin is a small pigment protein composed of globin and heme (Heme), capable of reversibly binding with oxygen to form MbO2, known as oxy-myoglobin, while Mb refers to deoxy-myoglobin. Within muscle cells, myoglobin plays a role in the transport and storage of oxygen.

MouseHemoglobin is a hemoglobin derived from mice. Hemoglobin is an iron-containing protein in red blood cells with oxygen-binding properties. It acts as an HO-1 inducer and consists of heme, enabling oxygen binding. Hemoglobin also transports gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and other sulfides. Additionally, it absorbs excess oxygen in tissues, functioning as an antioxidant.

Guinea Pig Hemoglobin is a hemoglobin derived from guinea pigs. Hemoglobin is an iron-containing protein in red blood cells with oxygen-binding capabilities. It acts as an HO-1 inducer and is composed of heme, which can bind to oxygen. Furthermore, hemoglobin transports other gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and sulfides. It also absorbs excess oxygen in tissues, functioning as an antioxidant.

Hemoglobin is an iron-containing protein found in red blood cells, noted for its ability to bind oxygen. As an HO-1 inducer, hemoglobin consists of heme groups capable of binding oxygen. Additionally, hemoglobin transports other gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and sulfides. It also functions as an antioxidant by absorbing unwanted oxygen from tissues.

RabbitHemoglobin is a hemoglobin derived from rabbits. Hemoglobin is an iron-containing protein in red blood cells with oxygen-binding properties. It acts as an HO-1 inducer and consists of heme, which can bind with oxygen. Hemoglobin also transports gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and sulfides. Additionally, it absorbs excess oxygen in tissues and serves as an antioxidant.

Myoglobin (human) is a small globular protein pigment consisting of globin bonded with ferriheme (Heme), allowing it to reversibly bind with oxygen, forming MbO2, known as oxymyoglobin, while Mb refers to deoxymyoglobin. Within muscle cells, myoglobin plays a crucial role in oxygen transport and storage.

Hemoglobin-CoA (Hemoglobin-coenzyme A) is a derivative of coenzyme A.