α-globin

3-(3,4-Dimethoxyphenyl)propanoic acid (3,4-Dimethoxyhydrocinnamic acid) is an orally active short-chain fatty acid (SCFAs) that promotes γ-globin gene expression and erythropoiesis in vivo, making it useful in treating beta hemoglobinopathies and other anemias.

Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.

Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).

Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.

Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.

Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM

TN1 is a potent inducer of fetal hemoglobin (HbF).

Haptoglobin, Phenotype 2-2 is a plasma protein that binds hemoglobin (Hb) to remove free hemoglobin and possesses antioxidant activity. It can be utilized in research related to kidney failure and cardiovascular diseases associated with diabetes.

RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).

FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.

Pepstatin (Pepsin Inhibitor S 735A) is an aspartate protease inhibitor that also inhibits HIV protease activity with specific and oral activity. Pepstatin inhibits autophagy.

Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.

Hemoglobin, which is the primary cause of sickle cell disease (SCD) abnormalities, can be utilized to determine fetal hemoglobin through time-resolved immunofluorescence assay [1].

Anti-Haptoglobin Antibody is a human-derived antibody expressed in CHO cells and targets Haptoglobin. It features a huIgG1 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 150 kDa. For isotype control, please refer to HumanIgG1kappa, Isotype Control.

Vasicinol (6-Hydroxypeganine), a pyrroloquinazoline alkaloid isolated from Adhatoda vasica (L.), Nees, is a sucrase inhibitor that inhibits the sucrose hydrolyzing activity of rat intestinal α-glucosidase, with a Ki value of 183 μM.Vasicinol is a HbF inducer. Vasicinol is an HbF inducer and can be used to study metabolic disorders and diabetes.

Hemoglobin (64-76) is a polypeptide molecule with the sequence GKKVITAFNEGLK.

Myoglobin is a small pigment protein composed of globin and heme (Heme), capable of reversibly binding with oxygen to form MbO2, known as oxy-myoglobin, while Mb refers to deoxy-myoglobin. Within muscle cells, myoglobin plays a role in the transport and storage of oxygen.

Hemoglobin-CoA (Hemoglobin-coenzyme A) is a derivative of coenzyme A.