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Polypodiales is the largest order of ferns, encompassing the majority of extant fern diversity found in forests, tropical regions, and temperate ecosystems. Members of this order produce secondary metabolites such as flavonoids, phenolic acids, terpenoids, and unique fern-specific compounds. In biomedical research, Polypodiales is studied for its antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities, although it remains less explored than flowering plants. Its vast diversity and ecological distribution make it an important source of novel natural products and a key system for studying fern evolution and secondary metabolism.
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