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Polypodiopsida is a class of ferns representing the majority of modern fern diversity across tropical, subtropical, and temperate ecosystems. Members produce secondary metabolites such as flavonoids, phenolic acids, terpenoids, and fern-specific bioactive compounds. In biomedical research, Polypodiopsida is studied for antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities, although it remains less characterized than flowering plants. Its evolutionary position makes it essential for understanding early vascular plant metabolism and non-seed plant chemical defense strategies.
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