4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 μM, Ki: 2.6 μM) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2.
Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 10-Hydroxycanthin-6-one has in vitro antimalarial activity; it also has cytotoxic activity, it could be a plant anticancer agent.
1-Methoxycarbonyl-beta-carboline-N-oxide is a natural product for research related to life sciences. The catalog number is TN6652 and the CAS number is 74690-74-7.
3β-Isodihydrocadambine 4-oxide is a natural product for research related to life sciences. The catalog number is TN6113 and the CAS number is 1092371-18-0.
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
1-Hydroxycanthin-6-one is a natural product of Picrasma, Simaroubaceae. The catalog number is TN2542 and the CAS number is 80787-59-3. 1-Hydroxycanthin-6-one can be used as a reference standard.
4-Methoxy-1-methoxycarbonyl-β-carboline is a natural product for research related to life sciences. The catalog number is TN6008 and the CAS number is 60807-25-2.