1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
Gomisin N, isolated from Schisandra chinensis, exhibits sedative and hypnotic bioactivity. It has potential applications in allergy treatment and inhibits proliferation while inducing apoptosis in cancer cells.
Schisantherin A (Wuweizi ester-A) is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent.
Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+ calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.
Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase
Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.
Sphenanlignan is a natural product of Schisandra, Schisandraceae. The catalog number is TN6406 and the CAS number is 866347-36-6. Sphenanlignan can be used as a reference standard.
1. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanhenol has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation.
Kadsuric acid is a natural product of Schisandra, Schisandraceae. The catalog number is TN5933 and the CAS number is 62393-88-8. Kadsuric acid can be used as a reference standard.
Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL.
4,4-di(4-Hydroxy-3-methoxyphenly)-2,3-dimethylbutanol has antioxidant and potential cytotoxic abilities, it also shows inhibition against HIV-1 integrase.
Isogomisin O is a natural product of Schisandra, Schisandraceae. The catalog number is TN4294 and the CAS number is 83916-76-1. Isogomisin O can be used as a reference standard.
Henricine is a natural product of Schisandra, Schisandraceae. The catalog number is TN6423 and the CAS number is 107783-46-0. Henricine can be used as a reference standard.
Ylangenyl acetate is a natural product of Schisandra, Schisandraceae. The catalog number is TN5360 and the CAS number is 90039-63-7. Ylangenyl acetate can be used as a reference standard.