Gentiakochianin (Swertianine), an anthrone from Gentianaceae, has vasodilatory activity, induces glioma cell cycle arrest in the G(2) M phase and inhibits proliferation, significantly reduces oxLDL-induced cell damage in EA.hy926 cells, inhibits ROS levels and up-regulated the activity of Akt CREB eNOS signaling pathway inhibited by oxLDL.