Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.

Sempervirine nitrate is an alkaloid extracted from Gelsemium elegans Benth., inhibiting HCC tumor growth and enhancing sorafenib's antitumor effects in vivo. It inhibits HCC proliferation and induces apoptosis by modulating the Wnt β-catenin pathway.

Humantenine, a naturally occurring indole alkaloid derived from *Gelsemium elegans*, HCT116 cell injury induced by humantenine was associated with the abnormal mRNA expression of m6A regulators