Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, proliferation, and mineralization, through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways.
Astragalus polysaccharide, a natural product derived from Astragalus propinquus, exhibits anticancer activity and has been shown to be effective in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM).
Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects.
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) exhibits a protective effect on rat hepatocytes, inhibits COX-2 activity, has antimicrobial properties, and is a promising anti-HIV agent. Additionally, it demonstrates scavenging activity against DPPH radicals and superoxide anions, alleviates osteoarthritis, and increases brain cell membrane fluidity in ischemia-reperfusion rats.
Isomucronulatol 7-O-glucoside, a natural product, has a molecular formula of C21H22O11. It is known for its glycosidic linkage between isomucronulatol and glucose, which contributes to its biological activity and potential therapeutic applications. This compound can be isolated from various plant species and has been studied for its pharmacological properties.
Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant.
Cyclocephaloside II is a natural product extracted from the roots of Astragalus brachypterus and Astragalus microcephalus, belonging to the class of cycloalkane triterpenoid saponins with potential biological activities. Astragalus saponin has the effect of improving myocardial function.