Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.

Anagyrine, is the responsible teratogen from teratogenic lupins, can produce congenital deformities in calves typical of crooked calf disease; it also can induce red cell aplasia, vascular anomaly, and skeletal dysplasia.(-)-Anagyrine and (-)--Methylcytisine have nematicidal activities against Pine Wood Nematodes.

13-Hydroxylupanine is a natural product from Cytisus scoparius.