Molecular glues Compound Database

Molecular glues facilitate the degradation or functional regulation of target proteins by stabilizing or inducing the binding between E3 ubiquitin ligases and target proteins. This makes targets previously considered 'undruggable,' such as transcription factors and scaffold proteins, accessible for therapeutic intervention. In oncology, molecular glues have successfully degraded key oncogenic proteins like BCL6 and IKZF1/3, with data showing an objective response rate (ORR) of 53% in multiple myeloma. In autoimmune diseases, molecular glues enable the precise regulation of inflammatory cytokine signaling pathways. Typically smaller than 500 Da, molecular glues combine the favorable pharmacokinetic properties of small molecules with the high specificity of biological macromolecules.