T6104 |
Cerdulatinib hydrochloride
|
1369761-01-2
|
98%
|
|
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
|
T13233 |
Tyk2-IN-3
|
1779493-12-7
|
98%
|
|
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
|
T14669 |
BMS-066
|
914946-88-6
|
98%
|
|
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
|
T15605 |
JAK/HDAC-IN-1
|
2284621-75-4
|
98%
|
|
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
|
T13564 |
AZ7550
|
1421373-99-0
|
98%
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
TN1096 |
Ginsenoside Ra1
|
83459-41-0
|
98%
|
|
Ginsenoside Ra1 is a component from ginseng. Ginsenoside Ra1 shows significant inhibitory effects on protein tyrosine kinase (PTK) activation induced by hypoxia/...
|
T6294 |
NVP-BSK805 2HCl (1092499-93-8(free base))
|
T6294
|
98%
|
|
NVP-BSK805 2HCl(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over JAK1, JAK3 and TYK2.
|
TQ0010 |
Brepocitinib
|
1883299-62-4
|
98%
|
|
PF-06700841 is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). It also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).
|
T60094 |
SU 4981
|
186610-88-8
|
100%
|
|
SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.
|
T6266 |
PP2
|
172889-27-9
|
95.65%
|
|
PP2 is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
|
T4511 |
ST271
|
106392-48-7
|
97.97%
|
|
ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
|
T7101 |
Tyrphostin AG30
|
122520-79-0
|
98%
|
|
Tyrphostin AG30 (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.
|
T1181 |
Gefitinib
|
184475-35-2
|
98%
|
|
Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 (IC50s: 37/37/26/57 nM).
|
TN1440 |
Beta-Hydroxyisovalerylshikonin
|
7415-78-3
|
98.16%
|
|
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
|
T6380 |
AMG 900
|
945595-80-2
|
98.4%
|
|
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases ...
|
T8697 |
ZAP-180013
|
873080-25-2
|
98.63%
|
|
ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
|
T3080 |
Pyridone 6
|
457081-03-7
|
98.74%
|
|
Pyridone 6(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying signi...
|
T6343 |
Geldanamycin
|
30562-34-6
|
98.83%
|
|
Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
|
T1929 |
Filgotinib
|
1206161-97-8
|
99.09%
|
|
GLPG0634(filgotinib) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
|
T6914 |
Oclacitinib maleate
|
1640292-55-2
|
99.17%
|
|
Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which...
|