TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat. No.	Product name	CAS No.	Purity
T35349	CU-CPD107	2573912-32-8	98%
T35349
T13182	Toll-like receptor modulator	926927-42-6	98%
T13182	Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T13168	TLR7 agonist 1	2178156-33-5	98%
T13168	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T10437	AZD8848	866269-28-5	98%
T10437	AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T15751	LHC-165	1258595-14-0	98%
T15751	LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
T15785	LPA1 receptor antagonist 1	1396006-71-5	98%
T15785	LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T16870	Selgantolimod	2004677-13-6	98%
T16870	Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
TP1938	RS 09	1449566-36-2	98%
TP1938	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
T17032	Telratolimod	1359993-59-1	98%
T17032	Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
TN4171	Grossamide	80510-06-1	98%
TN4171	Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
T14035	3M-011	642473-62-9	98%
T14035	3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
TN5138	Teuclatriol	152110-17-3	98%
TN5138	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312...
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TJS1779	Protosappanin A	102036-28-2	98%
TJS1779	Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammat...
T19675	SM360320	226907-52-4	98%
T19675	SM360320 is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to it...
T9570	Enpatoran	2101938-42-3	98%
T9570	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
T60052	BMS-905	2205846-49-5	98%
T60052	BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
T37292	M62812	613263-00-6	98%
T37292	TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects ...
T39669	TLR7/8/9-IN-1	2180127-82-4	98%
T39669	TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T39654	Afimetoran	2171019-55-7	98%
T39654	Afimetoran is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.