TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat. No.	Product name	CAS No.	Purity
T15751	LHC-165	1258595-14-0	98%
T15751	LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
TN5138	Teuclatriol	152110-17-3	98%
TN5138	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312...
T72035	TLR7/8/9 antagonist 2	2920729-91-3	98%
T72035	TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. TLR7/8/9 antagonist 2 inhibits HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC...
T15785	LPA1 receptor antagonist 1	1396006-71-5	98%
T15785	LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T14035	3M-011	642473-62-9	98%
T14035	3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
T16870	Selgantolimod	2004677-13-6	98%
T16870	Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
T13168	TLR7 agonist 1	2178156-33-5	98%
T13168	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T10437	AZD8848	866269-28-5	98%
T10437	AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
TP1938	RS 09	1449566-36-2	98%
TP1938	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
TN4171	Grossamide	80510-06-1	98%
TN4171	Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T13182	Toll-like receptor modulator	926927-42-6	98%
T13182	Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T39669	TLR7/8/9-IN-1	2180127-82-4	98%
T39669	TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T19675	SM360320	226907-52-4	98%
T19675	SM360320 is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to it...
T39654	Afimetoran	2171019-55-7	98%
T39654	Afimetoran is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
T2S0265	Robinin	301-19-9	98%
T2S0265	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
T60052	BMS-905	2205846-49-5	98%
T60052	BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
T23171	Polyinosinic-polycytidylic acid	24939-03-5	98%
T23171	Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-l...
T11598	IAXO-102	1115270-63-7	98%
T11598	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
T12516	Polyinosinic-polycytidylic acid sodium	42424-50-0	98%
T12516	Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...