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TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Cat No. product name
T0134 Imiquimod Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T6964 Resiquimod Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
T0194 Chloroquine phosphate Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
TN4171 Grossamide Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
T2911 Stevioside A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
T5S0045 Isofraxidin 1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
T10437 AZD8848 AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T8503 TLR4-IN-C34 TLR4-IN-C34 is an  inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T4080 Leonurine hydrochloride Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
T17032 Telratolimod Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
T7347 CU-CPT-8m CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
TN1936 Mogroside III-E Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
T15777 Loxoribine Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
T7302 CU-CPT9b CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HE...
T9570 Enpatoran Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
TQ0205 Procyanidin B1 Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
T16506 PF-4878691 PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
T4068 E6446 dihydrochloride E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
T4206 E6446 E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
T7860 SM-324405 SM 324405 is an  agonist of TLR7.
T22698 TLR3-IN-1 CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit ...
TN5138 Teuclatriol Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
T7317 CU-CPT-9a CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T11598 IAXO-102 IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
T15020 CU-CPT22 CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It comp...
T8316 1V209 1V209  is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
T39669 TLR7/8/9-IN-1 TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T5561 TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
T2S0265 Robinin Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
TP1938 RS 09 TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
T4231 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).
T16870 Selgantolimod Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
T5S0167 Atractylenolide I 1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T13167 TLR7/8 agonist 3 TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
T14513 BBIQ BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rece...
T13182 Toll-like receptor modulator Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T3502 C29 C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signa...
T12516 Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
T15017 CU-T12-9 CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines...
T7672 MD2-TLR4-IN-1 MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
TP1067 Pam3CSK4 TFA (112208-00-1 free base) Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
T35349 CU-CPD107
T3795 Corilagin Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
T15371 Gardiquimod Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
T4258 TLR7 agonist 2 TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
T14035 3M-011 3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
T5521 Bropirimine Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
TN2008 Okanin Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T3826 Polygalasaponin F Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
Imiquimod
T0134
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
Resiquimod
T6964
Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
Hydroxychloroquine sulfate
T0951
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
Chloroquine phosphate
T0194
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
Grossamide
TN4171
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
Stevioside
T2911
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
Isofraxidin
T5S0045
1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
AZD8848
T10437
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
TLR4-IN-C34
T8503
TLR4-IN-C34 is an  inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
Leonurine hydrochloride
T4080
Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
Telratolimod
T17032
Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
CU-CPT-8m
T7347
CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
Mogroside III-E
TN1936
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury i...
Loxoribine
T15777
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
CU-CPT9b
T7302
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing...
Enpatoran
T9570
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
Procyanidin B1
TQ0205
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
PF-4878691
T16506
PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
E6446 dihydrochloride
T4068
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
E6446
T4206
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
SM-324405
T7860
SM 324405 is an  agonist of TLR7.
TLR3-IN-1
T22698
CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit...
Teuclatriol
TN5138
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
CU-CPT-9a
T7317
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
IAXO-102
T11598
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinfla...
CU-CPT22
T15020
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It c...
1V209
T8316
1V209  is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
TLR7/8/9-IN-1
T39669
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
TLR7/8 agonist 1 dihydrochloride
T5561
TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
Robinin
T2S0265
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
RS 09
TP1938
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; en...
MD2-IN-1
T4231
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).
Selgantolimod
T16870
Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
Atractylenolide I
T5S0167
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reducti...
TLR7/8 agonist 3
T13167
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
BBIQ
T14513
BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rece...
Toll-like receptor modulator
T13182
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
C29
T3502
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signa...
Polyinosinic-polycytidylic acid sodium
T12516
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
CU-T12-9
T15017
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokine...
MD2-TLR4-IN-1
T7672
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
Pam3CSK4 TFA (112208-00-1 free base)
TP1067
Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
CU-CPD107
T35349
Corilagin
T3795
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
Gardiquimod
T15371
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection o...
TLR7 agonist 2
T4258
TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
3M-011
T14035
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
Bropirimine
T5521
Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
Okanin
TN2008
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
Polygalasaponin F
T3826
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and r...
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