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TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Cat. No. Product name CAS No. Purity Chemical Structure
T35349 CU-CPD107 2573912-32-8 98%
T13182 Toll-like receptor modulator 926927-42-6 98%
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T13168 TLR7 agonist 1 2178156-33-5 98%
TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T10437 AZD8848 866269-28-5 98%
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T15751 LHC-165 1258595-14-0 98%
LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
T15785 LPA1 receptor antagonist 1 1396006-71-5 98%
LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T16870 Selgantolimod 2004677-13-6 98%
Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
TP1938 RS 09 1449566-36-2 98%
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
T17032 Telratolimod 1359993-59-1 98%
Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
TN4171 Grossamide 80510-06-1 98%
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
T14035 3M-011 642473-62-9 98%
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
TN5138 Teuclatriol 152110-17-3 98%
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
TN3587 Capillarisin 56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TJS1779 Protosappanin A 102036-28-2 98%
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
T19675 SM360320 226907-52-4 98%
SM360320 is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to it...
T9570 Enpatoran 2101938-42-3 98%
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
T60052 BMS-905 2205846-49-5 98%
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
T37292 M62812 613263-00-6 98%
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects ...
T39669 TLR7/8/9-IN-1 2180127-82-4 98%
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T39654 Afimetoran 2171019-55-7 98%
Afimetoran is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
CU-CPD107
T35349
Toll-like receptor modulator
T13182
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
TLR7 agonist 1
T13168
TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
AZD8848
T10437
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
LHC-165
T15751
LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
LPA1 receptor antagonist 1
T15785
LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
Selgantolimod
T16870
Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
RS 09
TP1938
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
Telratolimod
T17032
Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
Grossamide
TN4171
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
3M-011
T14035
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
Teuclatriol
TN5138
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
SM360320
T19675
SM360320 is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to it...
Enpatoran
T9570
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
BMS-905
T60052
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatm...
M62812
T37292
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects ...
TLR7/8/9-IN-1
T39669
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
Afimetoran
T39654
Afimetoran is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
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