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Immunology/Inflammation TLR

TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Cat No. product name
T0194 Chloroquine diphosphateHOT Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
TP1938L RS09 2TFA (1449566-36-2 free base) RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro.  It acts as a...
T4080 Leonurine hydrochloride Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
T8316 1V209 1V209  is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
TP1067 Pam3CSK4 TFA (112208-00-1 free base) Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
T7860 SM 324405 SM 324405 is an  agonist of TLR7.
TQ0205 Procyanidin B1 Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
TQ0181 Resatorvid Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
T7672 MD2-TLR4-IN-1 MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
T7347 CU-CPT-8m CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T7302 CU-CPT9b CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing...
T7317 CU-CPT-9a CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T5561 TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
T4258 TLR7-agonist-1 TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
TN2008 Okanin Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T4068 E6446 dihydrochloride E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
T4206 E6446 E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
T4231 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).
T0134 Imiquimod Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T6898 Motolimod Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
T2911 Stevioside A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
T3502 C29 C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signa...
T3795 Corilagin Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
T6964 Resiquimod Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
TN1936 Mogroside IIIe Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury i...
T8503 TLR4-IN-C34 TLR4-IN-C34 is an  inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T8689 CHLOROQUINE Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
T10833 CL264 CL264, a specific agonist of TLR7, is used for innate immune signals research.
T23171 Poly(I:C) Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-l...
T22698 CU CPT 4a CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit...
TN5138 Teuclatriol Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
TN4171 Grossamide Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
T16870 Selgantolimod Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
T16506 PF-4878691 PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
T15785 LPA1 antagonist 1 LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T15777 Loxoribine Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
T15751 LHC-165 LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
T13182 Toll-like receptor modulator Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T12516 Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
T13168 TLR7 agonist 1 TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T13167 TLR7/8 agonist 3 TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
T11598 IAXO-102 IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinfla...
T10437 AZD8848 AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T12933 SM-276001 SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T15371 Gardiquimod Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection o...
T15020 CU-CPT22 CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It c...
T15017 CU-T12-9 CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokine...
T14513 BBIQ BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rece...
T14035 3M-011 3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
T10899 CU-CPT17e CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
T6846 Vesatolimod GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
Chloroquine diphosphate HOT
T0194CAS 50-63-5
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
RS09 2TFA (1449566-36-2 free base)
TP1938LCAS TP1938L
RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro.  It acts as a...
Leonurine hydrochloride
T4080CAS 24735-18-0
Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
1V209
T8316CAS 1062444-54-5
1V209  is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
Pam3CSK4 TFA (112208-00-1 free base)
TP1067CAS 112208-01-2
Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
SM 324405
T7860CAS 677773-91-0
SM 324405 is an  agonist of TLR7.
Procyanidin B1
TQ0205CAS 20315-25-7
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
Resatorvid
TQ0181CAS 243984-11-4
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
MD2-TLR4-IN-1
T7672CAS 2249801-12-3
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
CU-CPT-8m
T7347CAS 125079-83-6
CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
CU-CPT9b
T7302CAS 2162962-69-6
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing...
CU-CPT-9a
T7317CAS 2165340-32-7
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
TLR7/8 agonist 1 dihydrochloride
T5561CAS 1620278-72-9
TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
TLR7-agonist-1
T4258CAS 1642857-69-9
TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
Okanin
TN2008CAS 484-76-4
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
E6446 dihydrochloride
T4068CAS 1345675-25-3
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
E6446
T4206CAS 1219925-73-1
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
MD2-IN-1
T4231CAS 111797-22-9
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).
Imiquimod
T0134CAS 99011-02-6
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
Motolimod
T6898CAS 926927-61-9
Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
Hydroxychloroquine sulfate
T0951CAS 747-36-4
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
Stevioside
T2911CAS 57817-89-7
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
C29
T3502CAS 363600-92-4
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signa...
Corilagin
T3795CAS 23094-69-1
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
Resiquimod
T6964CAS 144875-48-9
Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
Mogroside IIIe
TN1936CAS 88901-37-5
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury i...
TLR4-IN-C34
T8503CAS 40592-88-9
TLR4-IN-C34 is an  inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
CHLOROQUINE
T8689CAS 54-05-7
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
CL264
T10833CAS 1510712-69-2
CL264, a specific agonist of TLR7, is used for innate immune signals research.
Poly(I:C)
T23171CAS 24939-03-5
Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-l...
CU CPT 4a
T22698CAS 1279713-77-7
CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit...
Teuclatriol
TN5138CAS 152110-17-3
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
Grossamide
TN4171CAS 80510-06-1
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Selgantolimod
T16870CAS 2004677-13-6
Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
PF-4878691
T16506CAS 532959-63-0
PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
LPA1 antagonist 1
T15785CAS 1396006-71-5
LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
Loxoribine
T15777CAS 121288-39-9
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
LHC-165
T15751CAS 1258595-14-0
LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
Toll-like receptor modulator
T13182CAS 926927-42-6
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
Polyinosinic-polycytidylic acid sodium
T12516CAS 42424-50-0
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
TLR7 agonist 1
T13168CAS 2178156-33-5
TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
TLR7/8 agonist 3
T13167CAS 642473-95-8
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
IAXO-102
T11598CAS 1115270-63-7
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinfla...
AZD8848
T10437CAS 866269-28-5
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
SM-276001
T12933CAS 473930-22-2
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
Gardiquimod
T15371CAS 1020412-43-4
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection o...
CU-CPT22
T15020CAS 1416324-85-0
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It c...
CU-T12-9
T15017CAS 1821387-73-8
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokine...
BBIQ
T14513CAS 1229024-57-0
BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rece...
3M-011
T14035CAS 642473-62-9
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
CU-CPT17e
T10899CAS 2109805-75-4
CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
Vesatolimod
T6846CAS 1228585-88-3
GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.