T0134 |
Imiquimod
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Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
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T6964 |
Resiquimod
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Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
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T0951 |
Hydroxychloroquine sulfate
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Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
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T0194 |
Chloroquine phosphate
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Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
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TN4171 |
Grossamide
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Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
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T2911 |
Stevioside
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A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
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T5S0045 |
Isofraxidin
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1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
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T10437 |
AZD8848
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AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
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T8503 |
TLR4-IN-C34
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TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
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T4080 |
Leonurine hydrochloride
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Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
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T17032 |
Telratolimod
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Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
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T7347 |
CU-CPT-8m
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CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
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TN1936 |
Mogroside III-E
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Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
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T15777 |
Loxoribine
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Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
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T7302 |
CU-CPT9b
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CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HE...
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T9570 |
Enpatoran
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Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
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TQ0205 |
Procyanidin B1
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Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
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T16506 |
PF-4878691
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PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
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T4068 |
E6446 dihydrochloride
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E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
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T4206 |
E6446
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E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
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T7860 |
SM-324405
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SM 324405 is an agonist of TLR7.
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T22698 |
TLR3-IN-1
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CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit ...
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TN5138 |
Teuclatriol
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Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
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T7317 |
CU-CPT-9a
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CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
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T11598 |
IAXO-102
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IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
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T15020 |
CU-CPT22
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CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It comp...
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T8316 |
1V209
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1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
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T39669 |
TLR7/8/9-IN-1
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TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
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T5561 |
TLR7/8 agonist 1 dihydrochloride
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TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
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T2S0265 |
Robinin
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Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
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TP1938 |
RS 09
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TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
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T4231 |
MD2-IN-1
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MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
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T16870 |
Selgantolimod
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Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
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T5S0167 |
Atractylenolide I
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1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
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T13167 |
TLR7/8 agonist 3
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TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
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T14513 |
BBIQ
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BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rece...
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T13182 |
Toll-like receptor modulator
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Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
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T3502 |
C29
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C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signa...
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T12516 |
Polyinosinic-polycytidylic acid sodium
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Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
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T15017 |
CU-T12-9
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CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines...
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T7672 |
MD2-TLR4-IN-1
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MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
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TP1067 |
Pam3CSK4 TFA (112208-00-1 free base)
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Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
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T35349 |
CU-CPD107
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T3795 |
Corilagin
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Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
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T15371 |
Gardiquimod
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Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of m...
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T4258 |
TLR7 agonist 2
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TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
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T14035 |
3M-011
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3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
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T5521 |
Bropirimine
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Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
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TN2008 |
Okanin
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Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
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T3826 |
Polygalasaponin F
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Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
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