T11900 |
LY-2584702 hydrochloride
|
1082948-81-9
|
98%
|
|
Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
|
T16896 |
SL 0101-1
|
77307-50-7
|
98%
|
|
SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an...
|
T0335 |
Sodium salicylate
|
54-21-7
|
99.98%
|
|
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
|
T11960 |
MBM-55
|
2083622-09-5
|
99.98%
|
|
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
|
T4301 |
AD80
|
1384071-99-1
|
99.9%
|
|
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
|
T2265 |
Bimiralisib
|
1225037-39-7
|
99.88%
|
|
Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the...
|
T6304 |
AT7867
|
857531-00-1
|
99.65%
|
|
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
|
T3079 |
GSK1838705A
|
1116235-97-2
|
99.63%
|
|
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
|
T2002 |
PF-4708671
|
1255517-76-0
|
99.41%
|
|
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC5...
|
T6171 |
BI-D1870
|
501437-28-1
|
99.39%
|
|
BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4).
|
T24398 |
Lenaldekar
|
418800-15-4
|
99.25%
|
|
Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway an...
|
T22422 |
S6K-18
|
1265789-88-5
|
99.23%
|
|
S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.
|
T6303 |
CCT128930
|
885499-61-6
|
99.18%
|
|
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
|
T14779 |
BRD7389
|
376382-11-5
|
99.17%
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
|
T2482 |
AT13148
|
1056901-62-2
|
99%
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
|
TN1712 |
Gossypin
|
652-78-8
|
98.97%
|
|
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the...
|
TQ0310 |
FMK
|
821794-92-7
|
98.93%
|
|
FMK is an irreversible inhibitor of RSK2 kinase.
|
T6878 |
LJI308
|
1627709-94-7
|
98.86%
|
|
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
|
T3836 |
Eudesmin
|
526-06-7
|
98.86%
|
|
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 ...
|
T6S1302 |
Carnosol
|
5957-80-2
|
98.67%
|
|
Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be ...
|