T5101 |
BW-A 78U
|
101155-02-6
|
99.65%
|
|
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.
|
T2334 |
Avanafil
|
330784-47-9
|
99.66%
|
|
Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
|
T4097 |
Vardenafil hydrochloride trihydrate
|
330808-88-3
|
99.66%
|
|
Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
|
T6054 |
GSK256066
|
801312-28-7
|
99.66%
|
|
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selec...
|
T10841 |
CM-675
|
1872466-47-1
|
99.67%
|
|
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...
|
T4041 |
Ziritaxestat
|
1628260-79-6
|
99.67%
|
|
GLPG-1690, an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
|
T6649 |
(S)-(+)-Rolipram
|
85416-73-5
|
99.71%
|
|
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous s...
|
T2129 |
Zaprinast
|
37762-06-4
|
99.73%
|
|
Zaprinast was an unsuccessful Clinicalal drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which succes...
|
T1083 |
Theophylline
|
58-55-9
|
99.74%
|
|
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
|
T8659 |
K-Ras-PDEδ-IN-1
|
1841464-21-8
|
99.74%
|
|
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
|
T3224 |
TBA-7371
|
1494675-86-3
|
99.74%
|
|
DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
|
T20792 |
W-7 hydrochloride
|
61714-27-0
|
99.75%
|
|
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
|
T6390 |
Anagrelide hydrochloride
|
58579-51-4
|
99.77%
|
|
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
|
T5940 |
Proxyphylline
|
603-00-9
|
99.79%
|
|
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
|
T1083L |
Theophylline monohydrate
|
5967-84-0
|
99.79%
|
|
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
|
T1112 |
2-(Hydroxymethyl)pyridine
|
586-98-1
|
99.79%
|
|
2-Pyridinylmethanol is an organic compound.
|
TN1266 |
3-O-Methylquercetin
|
1486-70-0
|
99.8%
|
|
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
|
T1713 |
IBMX
|
28822-58-4
|
99.80%
|
|
IBMX is a pan-phosphodiesterase (PDE) inhibitor (IC50s: 6.5/26.3/31.7 μM for PDE3/PDE4/PDE5).
|
T8919 |
Homo Sildenafil
|
642928-07-2
|
99.82%
|
|
Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.
|
T8515 |
Osoresnontrine
|
1189767-28-9
|
99.82%
|
|
BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory
|