PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T3783	Fraxin	524-30-1	99.19%
T3783	Fraxin (Fraxoside) is a glucoside of fraxetin.
T3465L	Vesnarinone HCl	T3465L	99.17%
T3465L	Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium ...
T27122	Dasantafil	569351-91-3	99.16%
T27122	Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.
T77631	Enpp/Carbonic anhydrase-IN-2	2883495-39-2	99.13%
T77631	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.0...
T27632	Isomazole	86315-52-8	99.12%
T27632	Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.
T16478	PF-04447943	1082744-20-4	99.11%
T16478	PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for ot...
T17284	Zardaverine	101975-10-4	99.11%
T17284	Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine'...
T19812	Propentofylline	55242-55-2	99.11%
T19812	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine s...
T33589	Nanterinone	102791-47-9	99.11%
T33589	Nanterinone (UK 61260), an orally available partial phosphodiesterase inhibitor, is a novel positive inotropic and balanced vasodilator compound.Nanterinone, whe...
T12267	NSP-805	125068-54-4	99.10%
T12267	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
T0892	Diphylline	479-18-5	99.1%
T0892	Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphyll...
T6462	Deltarasin	1440898-61-2	99.06%
T6462	Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
T15381	Gisadenafil	334826-98-1	99.06%
T15381	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
T27172	Difamilast	937782-05-3	99.04%
T27172	Difamilast is an inhibitor of phosphodiesterase IV.
T9239	RS-25344	152814-89-6	99.02%
T9239	RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vi...
T22851	ICI 63197	27277-00-5	99.02%
T22851	ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.
T83974	OPC18750 HCl	145364-90-5	98.92%
T83974	OPC18750 HCl is a potential phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disor...
T22086	HA 155	1229652-22-5	98.92%
T22086	HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.
TN1416	Ayanin	572-32-7	98.9%
TN1416	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylethe...
T63190	Cudetaxestat	1782070-21-6	98.84%
T63190	Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.