PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T5101	BW-A 78U	101155-02-6	99.65%
T5101	BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.
T2334	Avanafil	330784-47-9	99.66%
T2334	Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
T4097	Vardenafil hydrochloride trihydrate	330808-88-3	99.66%
T4097	Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
T6054	GSK256066	801312-28-7	99.66%
T6054	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selec...
T10841	CM-675	1872466-47-1	99.67%
T10841	CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...
T4041	Ziritaxestat	1628260-79-6	99.67%
T4041	GLPG-1690, an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
T6649	(S)-(+)-Rolipram	85416-73-5	99.71%
T6649	S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous s...
T2129	Zaprinast	37762-06-4	99.73%
T2129	Zaprinast was an unsuccessful Clinicalal drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which succes...
T1083	Theophylline	58-55-9	99.74%
T1083	Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
T8659	K-Ras-PDEδ-IN-1	1841464-21-8	99.74%
T8659	K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
T3224	TBA-7371	1494675-86-3	99.74%
T3224	DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
T20792	W-7 hydrochloride	61714-27-0	99.75%
T20792	W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
T6390	Anagrelide hydrochloride	58579-51-4	99.77%
T6390	Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
T5940	Proxyphylline	603-00-9	99.79%
T5940	Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
T1083L	Theophylline monohydrate	5967-84-0	99.79%
T1083L	Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T1112	2-(Hydroxymethyl)pyridine	586-98-1	99.79%
T1112	2-Pyridinylmethanol is an organic compound.
TN1266	3-O-Methylquercetin	1486-70-0	99.8%
TN1266	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
T1713	IBMX	28822-58-4	99.80%
T1713	IBMX is a pan-phosphodiesterase (PDE) inhibitor (IC50s: 6.5/26.3/31.7 μM for PDE3/PDE4/PDE5).
T8919	Homo Sildenafil	642928-07-2	99.82%
T8919	Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.
T8515	Osoresnontrine	1189767-28-9	99.82%
T8515	BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory