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PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.
Cat. No. Product name CAS No. Purity Chemical Structure
T5101 BW-A 78U 101155-02-6 99.65%
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.
T2334 Avanafil 330784-47-9 99.66%
Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
T4097 Vardenafil hydrochloride trihydrate 330808-88-3 99.66%
Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
T6054 GSK256066 801312-28-7 99.66%
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selec...
T10841 CM-675 1872466-47-1 99.67%
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...
T4041 Ziritaxestat 1628260-79-6 99.67%
GLPG-1690, an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
T6649 (S)-(+)-Rolipram 85416-73-5 99.71%
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous s...
T2129 Zaprinast 37762-06-4 99.73%
Zaprinast was an unsuccessful Clinicalal drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which succes...
T1083 Theophylline 58-55-9 99.74%
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
T8659 K-Ras-PDEδ-IN-1 1841464-21-8 99.74%
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
T3224 TBA-7371 1494675-86-3 99.74%
DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
T20792 W-7 hydrochloride 61714-27-0 99.75%
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
T6390 Anagrelide hydrochloride 58579-51-4 99.77%
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
T5940 Proxyphylline 603-00-9 99.79%
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
T1083L Theophylline monohydrate 5967-84-0 99.79%
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T1112 2-(Hydroxymethyl)pyridine 586-98-1 99.79%
2-Pyridinylmethanol is an organic compound.
TN1266 3-O-Methylquercetin 1486-70-0 99.8%
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
T1713 IBMX 28822-58-4 99.80%
IBMX is a pan-phosphodiesterase (PDE) inhibitor (IC50s: 6.5/26.3/31.7 μM for PDE3/PDE4/PDE5).
T8919 Homo Sildenafil 642928-07-2 99.82%
Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.
T8515 Osoresnontrine 1189767-28-9 99.82%
BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory
BW-A 78U
T5101
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.
Avanafil
T2334
Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
Vardenafil hydrochloride trihydrate
T4097
Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
GSK256066
T6054
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selec...
CM-675
T10841
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...
Ziritaxestat
T4041
GLPG-1690, an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
(S)-(+)-Rolipram
T6649
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous s...
Zaprinast
T2129
Zaprinast was an unsuccessful Clinicalal drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which succes...
Theophylline
T1083
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
K-Ras-PDEδ-IN-1
T8659
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
TBA-7371
T3224
DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
W-7 hydrochloride
T20792
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
Anagrelide hydrochloride
T6390
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
Proxyphylline
T5940
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
Theophylline monohydrate
T1083L
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
2-(Hydroxymethyl)pyridine
T1112
2-Pyridinylmethanol is an organic compound.
3-O-Methylquercetin
TN1266
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
IBMX
T1713
IBMX is a pan-phosphodiesterase (PDE) inhibitor (IC50s: 6.5/26.3/31.7 μM for PDE3/PDE4/PDE5).
Homo Sildenafil
T8919
Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.
Osoresnontrine
T8515
BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory
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