T17237 |
VPC 23019
|
449173-19-7
|
98%
|
|
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
|
T7393 |
ONO-7300243
|
638132-34-0
|
98%
|
|
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
|
T6085 |
PF-543
|
1415562-82-1
|
98%
|
|
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
|
T6347 |
Ki16198
|
355025-13-7
|
98%
|
|
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
|
T61112 |
SLF1081851
|
2763730-97-6
|
98%
|
|
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
|
T12821 |
S1PR1 modulator 1
|
2328109-05-1
|
98%
|
|
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
|
T12086 |
Mocravimod hydrochloride
|
509088-69-1
|
98%
|
|
Mocravimod hydrochloride is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
|
T15031 |
CYM50260
|
1355026-60-6
|
|
|
CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S...
|
T2026 |
CYM5442
|
1094042-01-9
|
96.65%
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine.
|
T7360 |
GSK2018682
|
1034688-30-6
|
97.78%
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
|
T3258 |
Ponesimod
|
854107-55-4
|
98.01%
|
|
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
|
T9199 |
GLPG2938
|
2130996-00-6
|
98.1%
|
|
GLPG2938 is a potent and selective antagonist of S1P2.
|
T3961 |
CYM-5541
|
945128-26-7
|
98.39%
|
|
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
|
T6108 |
Ki16425
|
355025-24-0
|
98.54%
|
|
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
|
T4016 |
BMS-986020
|
1257213-50-5
|
98.61%
|
|
BMS-986020 is a selective antagonist of LPA1.
|
T22703 |
CYM-5520
|
1449747-00-5
|
98.72%
|
|
noncompetitive allosteric agonist of S1P2
|
T28169 |
NIBR-0213
|
1233332-14-3
|
98.87%
|
|
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
|
T15629 |
JTE-013
|
383150-41-2
|
98.87%
|
|
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
|
T6403 |
Siponimod
|
1230487-00-9
|
99.29%
|
|
BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specifi...
|
T15032 |
CYM50308
|
1345858-76-5
|
99.43%
|
|
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
|