Aryl Hydrocarbon Receptor

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. More recently, it has been discovered that AhR is activated (or deactivated) by a number of endogenous indole derivatives such as kynurenine. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation.

Cat. No.	Product name	CAS No.	Purity
T39762	AHR antagonist 5 free base	2247950-42-9	98%
T39762	AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.
T10269	AHR antagonist 2	2338747-54-7	98%
T10269	AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
T4928	L-Kynurenine	2922-83-0	98%
T4928	L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
T0640	Benzyl butyl phthalate	85-68-7	98%
T0640	Butyl benzyl phthalate is used as a plasticizer for PVC.
T8980	SGA360	680611-86-3	98%
T8980	SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
T5281	Skatole	83-34-1	98%
T5281	Skatole is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
T10270	BAY 2416964	2242464-44-2	98%
T10270	BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the...
T1831	StemRegenin 1	1227633-49-9	98%
T1831	StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
T15410	GNF351	1227634-69-6	98%
T15410	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...
T2448	CH-223191	301326-22-7	98%
T2448	CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T21966	MeBIO	667463-95-8	98%
T21966	MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
T2707	Pifithrin-α hydrobromide	63208-82-2	98%
T2707	Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
T2623	PD98059	167869-21-8	98%
T2623	PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
T0878	Diosmin	520-27-4	98%
T0878	Diosmin is a bioflavonoid that strengthens vascular walls.
TQ0257	FICZ	172922-91-7	98%
TQ0257	FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
T1960	YL-109	36341-25-0	98%
T1960	YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
T5622	BAY-218	2162982-11-6	98%
T5622	AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T7202	ITE	448906-42-1	98%
T7202	ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T2947	Indole-3-carbinol	700-06-1	98%
T2947	Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T4607	CAY 10465	688348-33-6	98%
T4607	CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).