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Aryl Hydrocarbon Receptor

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. More recently, it has been discovered that AhR is activated (or deactivated) by a number of endogenous indole derivatives such as kynurenine. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation.
Cat. No. Product name CAS No. Purity Chemical Structure
T39762 AHR antagonist 5 free base 2247950-42-9 98%
AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.
T10269 AHR antagonist 2 2338747-54-7 98%
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
T4928 L-Kynurenine 2922-83-0 98%
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
T0640 Benzyl butyl phthalate 85-68-7 98%
Butyl benzyl phthalate is used as a plasticizer for PVC.
T8980 SGA360 680611-86-3 98%
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
T5281 Skatole 83-34-1 98%
Skatole is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
T10270 BAY 2416964 2242464-44-2 98%
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the...
T1831 StemRegenin 1 1227633-49-9 98%
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
T15410 GNF351 1227634-69-6 98%
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...
T2448 CH-223191 301326-22-7 98%
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T21966 MeBIO 667463-95-8 98%
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
T2707 Pifithrin-α hydrobromide 63208-82-2 98%
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
T2623 PD98059 167869-21-8 98%
PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
T0878 Diosmin 520-27-4 98%
Diosmin is a bioflavonoid that strengthens vascular walls.
TQ0257 FICZ 172922-91-7 98%
FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
T1960 YL-109 36341-25-0 98%
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
T5622 BAY-218 2162982-11-6 98%
AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T7202 ITE 448906-42-1 98%
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T2947 Indole-3-carbinol 700-06-1 98%
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T4607 CAY 10465 688348-33-6 98%
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
AHR antagonist 5 free base
T39762
AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.
AHR antagonist 2
T10269
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
L-Kynurenine
T4928
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
Benzyl butyl phthalate
T0640
Butyl benzyl phthalate is used as a plasticizer for PVC.
SGA360
T8980
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
Skatole
T5281
Skatole is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
BAY 2416964
T10270
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the...
StemRegenin 1
T1831
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
GNF351
T15410
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...
CH-223191
T2448
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
MeBIO
T21966
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
Pifithrin-α hydrobromide
T2707
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
PD98059
T2623
PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
Diosmin
T0878
Diosmin is a bioflavonoid that strengthens vascular walls.
FICZ
TQ0257
FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
YL-109
T1960
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
BAY-218
T5622
AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
ITE
T7202
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
Indole-3-carbinol
T2947
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
CAY 10465
T4607
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
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