T39762 |
AHR antagonist 5 free base
|
2247950-42-9
|
98%
|
|
AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.
|
T10269 |
AHR antagonist 2
|
2338747-54-7
|
98%
|
|
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
|
T4928 |
L-Kynurenine
|
2922-83-0
|
98%
|
|
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
|
T0640 |
Benzyl butyl phthalate
|
85-68-7
|
98%
|
|
Butyl benzyl phthalate is used as a plasticizer for PVC.
|
T8980 |
SGA360
|
680611-86-3
|
98%
|
|
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties.
|
T5281 |
Skatole
|
83-34-1
|
98%
|
|
Skatole is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
|
T10270 |
BAY 2416964
|
2242464-44-2
|
98%
|
|
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the...
|
T1831 |
StemRegenin 1
|
1227633-49-9
|
98%
|
|
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
|
T15410 |
GNF351
|
1227634-69-6
|
98%
|
|
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...
|
T2448 |
CH-223191
|
301326-22-7
|
98%
|
|
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
|
T21966 |
MeBIO
|
667463-95-8
|
98%
|
|
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
|
T2707 |
Pifithrin-α hydrobromide
|
63208-82-2
|
98%
|
|
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
|
T2623 |
PD98059
|
167869-21-8
|
98%
|
|
PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
|
T0878 |
Diosmin
|
520-27-4
|
98%
|
|
Diosmin is a bioflavonoid that strengthens vascular walls.
|
TQ0257 |
FICZ
|
172922-91-7
|
98%
|
|
FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
|
T1960 |
YL-109
|
36341-25-0
|
98%
|
|
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
|
T5622 |
BAY-218
|
2162982-11-6
|
98%
|
|
AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
|
T7202 |
ITE
|
448906-42-1
|
98%
|
|
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
|
T2947 |
Indole-3-carbinol
|
700-06-1
|
98%
|
|
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
|
T4607 |
CAY 10465
|
688348-33-6
|
98%
|
|
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
|