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Aminopeptidase

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.
Cat. No. Product name CAS No. Purity Chemical Structure
T14121 Actinonin 13434-13-4 98%
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...
T16684 Puromycin aminonucleoside 58-60-6 98%
Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T28482 Firibastat 648927-86-0 98%
QGC-001 is a glutamyl aminopeptidase antagonist.
T3715 Acebilustat 943764-99-6 98%
Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
T60040 α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid 128253-12-3 98%
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodolog...
T21859 ARM1 68729-05-5 98%
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T21696 SC-57461A 423169-68-0 98%
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
T6301 Tosedostat 238750-77-1 98%
CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly in...
TQ0047 DG051 929915-58-2 98%
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
T7958 Methyl arachidate 1120-28-1 98%
Methyl Icosanoate is an esterified form of arachidic acid
T5652 L(+)-Leucinol 7533-40-6 98%
L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
T3529 Bestatin hydrochloride 65391-42-6 98%
Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
T1257 Bestatin 58970-76-6 98%
Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential...
T2830 Betulinic acid 472-15-1 98%
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
T61278 Aminopeptidase-IN-1 374102-08-6 98%
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and mem...
Actinonin
T14121
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...
Puromycin aminonucleoside
T16684
Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
Firibastat
T28482
QGC-001 is a glutamyl aminopeptidase antagonist.
Acebilustat
T3715
Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
T60040
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodolog...
ARM1
T21859
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
SC-57461A
T21696
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
Tosedostat
T6301
CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly in...
DG051
TQ0047
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
Methyl arachidate
T7958
Methyl Icosanoate is an esterified form of arachidic acid
L(+)-Leucinol
T5652
L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
Bestatin hydrochloride
T3529
Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
Bestatin
T1257
Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential...
Betulinic acid
T2830
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
Aminopeptidase-IN-1
T61278
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and mem...