Aminopeptidase

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.

Cat. No.	Product name	CAS No.	Purity
T14121	Actinonin	13434-13-4	98%
T14121	Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...
T16684	Puromycin aminonucleoside	58-60-6	99.97%
T16684	Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T28482	Firibastat	648927-86-0	99.88%
T28482	Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A ...
T3715	Acebilustat	943764-99-6	99.47%
T3715	Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
T60040	α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid	128253-12-3	99.36%
T60040	α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodolog...
T21859	ARM1	68729-05-5	99.28%
T21859	ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T21696	SC-57461A	423169-68-0	99.14%
T21696	SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
TQ0047	DG051	929915-58-2	98.12%
TQ0047	DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
T7958	Methyl arachidate	1120-28-1	98%
T7958	Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid
T5652	L(+)-Leucinol	7533-40-6	98%
T5652	L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
T3529	Bestatin hydrochloride	65391-42-6	98%
T3529	Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
T1257	Bestatin	58970-76-6	100%
T1257	Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide wit...
T2830	Betulinic acid	472-15-1
T2830	Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
T61278	Aminopeptidase-IN-1	374102-08-6	98%
T61278	Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and mem...
T6301	Tosedostat	238750-77-1	98%
T6301	Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted int...
T28698	SC-22716	262451-89-8	98%
T28698	SC-22716 is an orally active leukotriene A4 (LTA4) hydrolase inhibitor.SC-22716 has potential anti-inflammatory activity and may be used in the study of inflamma...