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Aminopeptidase

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T14121 Actinonin 13434-13-4 98%
Actinonin
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...
T16684 Puromycin aminonucleoside 58-60-6 99.97%
Puromycin aminonucleoside
Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T28482 Firibastat 648927-86-0 99.88%
Firibastat
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A ...
T3715 Acebilustat 943764-99-6 99.47%
Acebilustat
Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
T60040 α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid 128253-12-3 99.36%
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodolog...
T21859 ARM1 68729-05-5 99.28%
ARM1
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T21696 SC-57461A 423169-68-0 99.14%
SC-57461A
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
T61278 Aminopeptidase-IN-1 374102-08-6 98.37%
Aminopeptidase-IN-1
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and mem...
TQ0047 DG051 929915-58-2 98.12%
DG051
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
T7958 Methyl arachidate 1120-28-1 98%
Methyl arachidate
Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid
T5652 L(+)-Leucinol 7533-40-6 98%
L(+)-Leucinol
L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
T3529 Bestatin hydrochloride 65391-42-6 98%
Bestatin hydrochloride
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
T1257 Bestatin 58970-76-6 100%
Bestatin
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide wit...
T6301 Tosedostat 238750-77-1
Tosedostat
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted int...
T2830 Betulinic acid 472-15-1
Betulinic acid
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
T28698 SC-22716 262451-89-8 98%
SC-22716
SC-22716 is an orally active leukotriene A4 (LTA4) hydrolase inhibitor.SC-22716 has potential anti-inflammatory activity and may be used in the study of inflamma...
Actinonin
T14121
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a...
Puromycin aminonucleoside
T16684
Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
Firibastat
T28482
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A ...
Acebilustat
T3715
Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
T60040
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodolog...
ARM1
T21859
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
SC-57461A
T21696
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
Aminopeptidase-IN-1
T61278
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and mem...
DG051
TQ0047
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).
Methyl arachidate
T7958
Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid
L(+)-Leucinol
T5652
L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
Bestatin hydrochloride
T3529
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
Bestatin
T1257
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide wit...
Tosedostat
T6301
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted int...
Betulinic acid
T2830
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
SC-22716
T28698
SC-22716 is an orally active leukotriene A4 (LTA4) hydrolase inhibitor.SC-22716 has potential anti-inflammatory activity and may be used in the study of inflamma...
TargetMol