zvadfmk

Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 μM.

Z-VAD is a competitive, irreversible, and broad-spectrum caspase inhibitor that inhibits all caspases except caspase-2, against which it is less effective. This compound reduces radiation-induced apoptosis and can induce autophagy and necrosis in radiation-treated xenografts of MDA-MB-231 and H460 in mice. When combined with radiation, Z-VAD significantly delays tumor growth and exhibits substantial anti-angiogenic effects in cancer xenografts.

Z-VAD(OMe)-FMK is a pan-caspase inhibitor with irreversible properties; Z-VAD(OMe)-FMK is also an inhibitor of ubiquitin C terminal hydrolase L1 (UCHL1), which is irreversibly modified by targeting the UCHL1 active site.