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(2)
By Target- PI3K
- mTOR(2)
- Src(1)
- p38 MAPK(1)
- Others(1)
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Results for "
wye687
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- WYE-687T67321062161-90-3WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) without affecting P-AKT(T308). Its selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
- $32
SizeQTY - WYE-687 dihydrochlorideT722701702364-87-1WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibits inhibitory effects on PI3Kα and PI3Kγ, with IC50 values of 81 nM and 3.11 μM, respectively.
- $5,130
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