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By Target- Bcl-2 Family
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Results for "
wx2-43
" in TargetMol Product Catalog.- Inhibitors & Agonists1
WX2-43
T71767723754-14-1
WX2-43 is a PRMT5-KLF4 inhibitor. Biotin-labeled WX2-43 binds to GST-PRMT5 with a dissociation constant Kd of 11.0 nM. It binds to the L400 to M500 amino acid region of PRMT5 protein, effectively blocking the interaction between KLF4 and PRMT5 and inhibiting KLF4 methylation modification. Functionally, WX2-43 downregulates p21 expression and upregulates Bax level, thereby suppressing the progression of triple-negative breast tumors. It can be applied to mechanism research of triple-negative breast cancer and colorectal cancer.
- $30
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