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Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.

(+)-Schisandrin B is a natural lignan demonstrating inhibitory activity against HIV-1 in H9 cells (EC50 = 0.8 mg/L).

1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.

Schisandrin B (Standard) is a reference standard for research and analysis in studies involving Schisandrin B. Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.