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Results for "
verrucarin a
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Natural Products2
Verrucarin A
T412403148-09-2
Verrucarin A (Muconomycin A) is a Type D macrocyclic mycotoxin. Verrucarin A (VA), derived from the pathogen fungus Myrothecium verrucaria, is a protein synthesis inhibitor that inhibits the growth of leukemia cell lines and activates caspases, apoptosis, and inflammatory signaling in macrophages. It effectively increases the phosphorylation of p38 MAPK and diminishes the phosphorylation of ERK Akt. Additionally, Verrucarin A causes cell cycle deregulation through the induction of p21 and p53 [1] [2].
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8-Acetylverrucarin L
Verrucarin L acetate
TN801677101-88-3
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin known for its antitumor and antibacterial properties. It exhibits cytotoxicity against cancer cells HCT116 and A2780S with an IC100 of 9.77 ng mL for both. Moreover, 8-Acetylverrucarin L demonstrates antifungal activity against Saccharomyces cerevisiae, Candida albicans, and Geotrichum candidum.
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(-)-Verrucarol
TN89442198-92-7
(-)-Verrucarol is a monocyclic trichothecene sesquiterpene and a hydrolysis product of natural Verrucarin A. It is utilized for cancer research.
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