val cit pab oh

Val-cit-PAB-OH is an ADC linker that is cleavable.

Azido-PEG3-Val-Cit-PAB-OH is a cleavable three-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker used in ADC synthesis [1].

Azido-PEG4-Val-Cit-PAB-OH is a 4-unit PEG ADC linker and a PEG-based PROTAC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2].

Mal-PEG2-Val-Cit-amido-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Mal-PEG4-Val-Cit-PAB-OH, a cleavable 4-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-amido-PEG2-Val-Cit-PAB-OH is a bi-functional polyethylene glycol (PEG) linker, composed of two PEG units, that is cleavable and specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

OPSS-Val-Cit-PAB-OH is an ADC linker used for the synthesis of antibody-drug conjugates (ADCs) [1].

OH-Glu-Val-Cit-PAB-MMAE is a compound consisting of a cleavable ADC linker (OH-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE), used in the synthesis of antibody-drug conjugates (ADCs) [1].

Compound L5-1c, known as Glu(OtBu)-Val-Cit-PAB-OH, is a non-cleavable ADC linker. This compound has been utilized in the synthesis of protein-tubulysin conjugates [1].

Alkyne-Val-Cit-PAB-OH is a cleavable ADC linker.

Azidoacetyl-Val-Cit-PAB-OH is a cleavable ADC linker.

Fmoc-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized to attach reactive groups (e.g., PNP) for drug payload conjugation. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases, enabling efficient payload release into cells.

NH2-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker composed of a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB is suitable for coupling with reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine enables versatile reactions, including coupling with carboxylic acids, reductive amination with ketones or aldehydes, and more specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide undergoes cleavage by intracellular proteases, allowing efficient payload delivery via an elimination mechanism within the PAB structure.

Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB is useful for attaching reactive groups (e.g., PNP) to bind with drug payloads. Acidic conditions can remove the Boc protecting group, exposing the primary amine for conjugation reactions to form amides. The Val-Cit-PAB segment can be cleaved by intracellular proteases, allowing efficient payload release within cells.

Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.

Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.

NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker with a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB group facilitates conjugation reactions with groups like PNP for binding drug payloads. The primary amine is versatile in participating in reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and more specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.

Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker that features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB component is suitable for attaching reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine is versatile for reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, or other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular cathepsins, allowing efficient payload delivery via an elimination mechanism through the PAB structure.

Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporating the tubulin inhibitor monomethyl auristatin E (MMAE) and linked via the cleavable Azido-PEG4-Val-Cit-PAB-OH.