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(2)
By Target- Histone Methyltransferase
- PROTACs(1)
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Results for "
unc0642
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- UNC0642UNC-0642, UNC 0642T41661481677-78-4UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
- $34
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Cited - MS-8709MS8709, MS 8709T2024583060730-06-2MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.
- $41
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