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By Target- Histone Methyltransferase
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Results for "
unc0642
" in TargetMol Product Catalog- Inhibitors & Agonists2
UNC0642
UNC-0642, UNC 0642
T41661481677-78-4
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
- $34
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QTY
MS-8709
MS8709, MS 8709
T2024583060730-06-2
MS-8709 is a G9a/GLP PROTAC Degrader (DC50(G9a) = 274 nM; DC50(GLP) = 260 nM) that induces G9a/GLP degradation in a concentration-, time-, and ubiquitin-proteasome system (UPS)-dependent manner. It shows higher selectivity for G9a/GLP over other methyltransferases, without affecting G9a/GLP mRNA expression. In addition, MS-8709 demonstrates superior inhibition of prostate cancer, leukemia, and lung cancer cell growth compared to its parent compound, the G9a/GLP inhibitor UNC0642, and possesses favorable murine pharmacokinetic properties for in vivo efficacy studies.
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