tyrosine kinasein1

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor that acts on KDR, Flt-1, FGFR1, and PDGFRα with IC50 values of 4 nM, 20 nM, 4 nM, and 2 nM, respectively.

Tyrosine kinase-IN-11 is a potent multi-target tyrosine kinase inhibitor. It suppresses proliferation and migration in drug-resistant solid tumor cell lines by competitively binding to the kinase ATP-binding domain and blocking growth factor receptor phosphorylation cascades.