tubercidin

Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.

Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity.

7-Deazaadenosine 5'-phosphate (Tubercidin 5'-phosphate; 7-Deaza-AMP) is a potential substrate and competitive inhibitor of enzymes that interact with 5′-adenosine monophosphate. As a nucleotide derivative, 7-Deazaadenosine 5'-phosphate modulates cellular functions by influencing intracellular signaling pathways, particularly those involving AMP.

Tubercidin5'-triphosphate (7-Deazaadenosine 5'-triphosphate) tetrasodium is a nucleoside analogue and serves as an active metabolite of Tubercidin.

Tubercidin 5'-diphosphate (7-Deazaadenosine 5'-diphosphate) is a modified nucleotide and a metabolite derived from tubercidin. It is formed through the phosphorylation of tubercidin and can be further phosphorylated to produce the active metabolite 7-deazaadenosine-5’-O-triphosphate.

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Anhydro-nucleosides

Nucleoside Derivatives - 7-Deaza-purine nucleosides; 2',3'-Dideoxy nucleosides

7-Deazaadenosine-5'-O-diphosphate, a modified nucleotide and metabolite of tubercidin, is generated through phosphorylation of tubercidin and further undergoes phosphorylation to become the active metabolite 7-deazaadenosine-5'-O-triphosphate.

5-Hydroxymethyltubercidin is a semisynthetic antibiotic derived from tubercidin-5-carboxylic acid.

2'-Deoxytubercidin 5'-triphosphate (C7dATP) sodium is a deoxyadenosine triphosphate (dATP) analog designed to reduce electrophoretic mobility anomalies caused by compression at G or A residues, thereby enhancing the quality of DNA sequencing data.

Xylotubercidin is a biochemical.

5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

Bromotubercidin is a reversible inhibitor of RNA synthesis. Bromotubercidin is a biochemical.

Nucleoside - 7-deazapurine nucleoside, fluoronucleoside,  Arabino-nucleoside

Nucleoside Derivatives - 7-Deaza-purine nucleosides; 3'-Deoxy nucleosides