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Results for "

tsp1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    6
    TargetMol | Inhibitors_Agonists
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THBS1 Protein, Human, Recombinant (His)
TSP1, TSP, Thrombospondin-1, THBS1
TMPJ-00802
Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic, hypotensive, and antithrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGF R2 signaling on vascular endothelial cells(EC), and destabilizes adhesive contacts between EC. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP).
  • Inquiry Price
7-10 days
Size
QTY
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Granzyme A/GZMA Protein, Mouse, Recombinant (His)
T cell-specific serine protease 1 (TSP-1), Mtsp-1, Gzma, Granzyme A, Fragmentin-1, CTLA-3, Ctla-3, Ctla3, Autocrine thymic lymphoma granzyme-like serine protease
TMPH-02687
Expression system: E. coli
Length: 29-260, Full Length of Mature Protein
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable