tp 319

CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.

HIV (gp41) Fragment AVGIGA is a polypeptide molecule with the sequence AVGIGA.

HIV-1 tat Protein (49-57) is a polypeptide molecule with the sequence RKKRRQRRR.

Laminin Penta Peptide, amide is a polypeptide molecule with the sequence YIGSR-NH2.

[DTrp6]-LH-RH, amide is a polypeptide molecule with the sequence Glp-HWSY-DTrp-LRPG-NH2.

Mage-1 Antigen (161-169), human is a polypeptide molecule with the sequence EADPTGHSY.

WNRQLYPEWTEAQRLD is a polypeptide molecule with the sequence WNRQLYPEWTEAQRLD.

Diazepam-Binding Inhibitor Fragment, human is a polypeptide molecule with the sequence QATVGDINTERPGMLDFTGK.

Orexin B, canine is a polypeptide molecule with the sequence RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2.

PAR-4 (1-6), mouse is a polypeptide molecule with the sequence GYPGKF.

Tyr-Ile-Tyr-Gly-Ser-Phe-Lys is a polypeptide molecule with the sequence YIYGSFK.

Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2's neurotoxic properties are implicated in the progression of neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD) [1] [2] [3] [4].