tp 271

TP-271, a tetracyclines antibiotic, is used potentially for the treatment of community-acquired bacterial pneumonia (CABP).

HYNIC-iPSMA TFA serves as a ligand in the molecular imaging of tumors. It comprises HYNIC (6-hydrazinonicotinamide), which is employed to bind radioactive isotopes to target molecules, and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen), a specific inhibitor of PSMA. 68GA-labeled iPSMA is utilized for detecting prostate cancer through PET imaging. Additionally, 99mTc-EDDA/HYNIC-iPSMA TFA exhibits remarkable specificity and sensitivity.

Tertiapin (reduced) is a synthetic bee venom peptide characterized by disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It acts as an inhibitor of inward-rectifying potassium channels (potassium Channel) and can also block the activity of calcium-activated large conductance potassium channels. Tertiapin (reduced) is utilized in research related to diseases such as rheumatoid arthritis and multiple sclerosis.

Cyclo(CLLFVY) is an inhibitor of hypoxia-inducible factor-1 (HIF-1), exhibiting half-maximal inhibitory concentrations (IC50) of 19 μM in U2OS cells and 16 μM in MCF-7 cells. It binds to the PAS-B domain of HIF-1α, inhibiting the dimerization and transcriptional activity of HIF-1. Moreover, cyclo(CLLFVY) downregulates the expression of hypoxia response genes (such as VEGF and CAIX), demonstrating antitumor effects against HIF-1-related cancers.

Pardaxin P 4 is an antimicrobial peptide found in the secretions of the Red Sea Moses sole (Red Sea Moses sole). It functions as a biolfilm perforating agent, interacting with phospholipid bilayers of varying compositions to induce cytotoxicity and pore formation. Pardaxin P 4 is used in the research of antimicrobial.

Kisspeptin antagonist p271 is a Kisspeptin inhibitor with cell-penetrating properties. It blocks the binding of endogenous Kisspeptin to GPR54 on pituitary growth hormone cells, removing the inhibition on growth hormone secretion. This compound specifically and significantly stimulates the release of growth hormone while inhibiting luteinizing hormone, without affecting prolactin or cortisol levels. Kisspeptin antagonist p271 may be used in research related to growth hormone deficiency disorders.