tolcapone

Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor employed as an adjunctive therapy with levodopa and carbidopa in the treatment of Parkinson's disease.

Tolcapone-D7 is a deuterium-labeled Tolcapone. Tolcapone (T6708) is a selective and orally active inhibitor of COMT.

3-O-Methyl Tolcapone-D7 is a deuterated compound of 3-O-Methyl Tolcapone. 3-O-Methyl Tolcapone (T10119) has a CAS number of 134612-80-9.

3-O-Methyltolcapone-D7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (T10119) (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease.

3-O-Methyltolcapone (Ro 40-7591), a metabolite of Tolcapone, is a potent COMT inhibitor that crosses the blood-brain barrier and can be used for the treatment of Parkinson's disease.

Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Ro 61-1448 is a metabolite of tolcapone, a catechol-O-methyltransferase inhibitor.