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By Target- IL Receptor
- MyD88(1)
- p38 MAPK(1)
- Others(1)
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Results for "
tir1/afb receptor
" in TargetMol Product Catalog- Inhibitors & Agonists2
EM 163 
T411421206480-93-4In house
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP)-triggered protein synthesis.
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