thermal stabilization

BMS-202 (PD1-PDL1 inhibitor 2) is a non-peptide PD-1/PD-L complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 binds to PD-L1 with high affinity and blocks human PD-1/PD-L interactions, exhibiting antitumor activity.

C16 Ceramide (d16:1,C16:0) is a bioactive sphingolipid that induces the formation and thermal stabilization of ordered phases and gel phases enriched in palmitoyl sphingomyelin domains within palmitoyl phosphatidylcholine (POPC) bilayers. It is found in human erythrocyte sphingomyelin.

Antioxidant 168 (Tris(2,4-di-tert-butylphenyl) phosphite) is a high-performance solid organophosphite secondary antioxidant. As an essential additive in the processing of polymer materials, Antioxidant 168 is widely used for stabilization treatment during the processing of polyolefins, polycarbonates, ABS, and other materials, owing to its low volatility, excellent thermal stability, and outstanding hydrolysis resistance. The core mechanism of action of Antioxidant 168 lies in its ability to efficiently decompose hydroperoxides generated by thermal oxidation during material processing, thereby inhibiting the degradation chain reaction of polymers.

HDAC8-IN-3 (compound P19) is a highly potent HDAC8 inhibitor with an IC50 value of 9.3 μM, inducing thermal stabilization, cytotoxicity, and apoptosis specifically in leukemic cell lines [1].

SHP244 is an allosteric inhibitor of SHP2 with modest thermal stabilization of the enzyme.