temporin a

Temporin A, a short alpha-helical antimicrobial peptide derived from the skin of Rana temporaria, exhibits a wide-ranging efficacy against Gram-positive bacteria. It directly interacts with the cell membrane of microorganisms and remains non-toxic to erythrocytes at antimicrobial concentrations. Additionally, Temporin A demonstrates antifungal properties against yeast-like Candida albicans.

Temporin A acetate is a natural short α-helical antimicrobial peptide that targets microbial cell membranes and exhibits inhibitory effects against a broad spectrum of Gram-positive bacteria and fungi.

Temporin L, a potent antimicrobial peptide, exhibits activity against Gram-negative bacteria and yeast strains, as well as demonstrating antiendotoxin properties.

Temporin B acetate is an antimicrobial peptide effective against Gram-positive bacteria, exhibiting lower activity against Gram-negative bacteria.

Temporin B, an antimicrobial peptide, is effective against Legionella pneumophila [1].

Temporin C is an antimicrobial peptide effective against *Legionella pneumophila* [1].

Temporin F exhibits antimicrobial activity against Legionella pneumophila [1].

Temporin G, an antimicrobial peptide, exhibits activity against Legionella pneumophila [1].

Temporin K, an antimicrobial peptide, exhibits effectiveness against Legionella pneumophila [1].

Temporin-GHc exhibits antibacterial activity with an MBIC50 of 6 μM and antibiofilm activity with an MBEC50 of 25 μM at 24 h [1].

Temporin-GHd demonstrates antibacterial properties against Streptococcus mutans with a minimum inhibitory concentration (MIC) of 13.1 μM and a minimum bactericidal concentration (MBC) of 26 μM. It enhances the permeability of the bacterial cell membrane, leading to damage and leakage of cellular components. At elevated concentrations, Temporin-GHd disrupts existing biofilms and can bind to bacterial DNA, thereby hindering DNA migration.

Temporin SHF is an antimicrobial peptide with broad-spectrum antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and yeast, and is non-hemolytic. Its mechanism of action is to disrupt the accumulation of acyl chains in the anionic lipid bilayer of microorganisms, resulting in the formation and disintegration of microbial membrane cracks. This compound has application potential in antibacterial development.

Temporin-Sha is an antimicrobial peptide known for its broad-spectrum biological activity. It is effective against Gram-positive bacteria (such as Listeria, MIC= 6.25 μM), Gram-negative bacteria (such as Escherichia coli, MIC= 10 μM), and resistant strains like Methicillin-resistant Staphylococcus aureus. Additionally, Temporin-Sha inhibits Candida albicans (MIC= 25 μM), Saccharomyces cerevisiae (MIC= 12 μM), Leishmania promastigotes and amastigotes (IC50= 9-20 μM), and Trypanosomes (IC50= 17 μM). It also exhibits antiviral activity against HSV-1 and shows anticancer properties, displaying cytotoxicity towards breast cancer cells MCF-7 and lung cancer cells H460.