tebuconazole

Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).

Tebuconazole-d4 is the deuterium-labeled form of Tebuconazole. Tebuconazole, an orally active triazole fungicide, inhibits CYP51, with IC50 values of 0.9 μM for Candida albicans CYP51 (CaCYP51) and 1.3 μM for the truncated human CYP51 (Δ60HsCYP51). It induces lipid accumulation and oxidative stress in HepG2 cells, reduces viability and proliferation of MAC-T cells, triggers endoplasmic reticulum stress-mediated apoptosis, and increases oxidative stress in MAC-T cells.

MDL-27048 is a powerful and reversible microtubule inhibitor.

Antibacterial agent 243 is a potent antimicrobial compound with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. It induces hyphal contraction and collapse, triggers the accumulation of reactive oxygen species within cells, modulates antioxidant enzyme activity, initiates lipid peroxidation, and ultimately causes irreversible oxidative damage to Valsa mali cells.