tco-peg8-tco

TCO-PEG8-TCO, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG8-acid, a PEG-based linker for PROTACs, joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG8-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG8-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG8-TFP ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

(S)-TCO-PEG8-acid is a click chemistry PEG linker characterized by a terminal carboxylic acid (COOH) group. This terminal group reacts with primary amine groups to form stable amide bonds. As a PEG-based PROTAC linker, (S)-TCO-PEG8-acid is utilized in PROTAC synthesis. It is longer compared to (S)-TCO-PEG3-acid.

(R)-TCO-PEG8-acid, an ADC linker containing 8 PEG units, utilizes its TCO group to facilitate an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

(S)-TCO-PEG8-NHS ester, an ADC linker featuring 8 PEG units, actively employs its TCO group to facilitate an inverse electron demand Diels-Alder reaction (iEDDA) with molecules possessing Tetrazine groups.

Me-Tet-PEG8-NH2 (hydrochloride), an ADC Linker featuring 2 PEG units, incorporates a Tetrazine group that facilitates a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds containing TCO groups.

(R)-TCO-PEG8-NHS ester, an ADC linker featuring 8 polyethylene glycol (PEG) units, utilizes its TCO group to engage in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

Me-Tet-PEG8-Maleimide, an ADC Linker featuring 8 PEG units, incorporates a Tetrazine group that enables it to specifically undergo an inverse electron demand Diels-Alder reaction (iEDDA) with compounds possessing TCO groups. Additionally, its maleimide group (-Maleimide) is prone to degradation in aqueous media, making it suitable for use in drug delivery studies.

Me-Tet-PEG8-NHBoc, an ADC Linker featuring 8 PEG units, leverages its Tetrazine group to partake in a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds containing TCO groups.

Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker with a terminal methyltetrazine group, allowing it to react with TCO-containing compounds without the need for Cu-catalysis or high temperatures. It also features a terminal amine capable of specifically and efficiently reacting with NHS esters. The PEG spacer enhances water solubility.