tco-amine

TCO-amine is an alkyl chain PROTAC Linker for synthesizing PROTAC molecules.

TCO-C3-PEG3-C3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(S)-TCO-PEG3-amine is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG2-amine is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG4-amine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective protein degradation by leveraging the ubiquitin-proteasome system within cells. [PROTACs]

TCO-PEG6-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG8-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-SS-amine, a cleavable linker crucial in ADC synthesis, joins cytotoxic drugs to antibodies for precise delivery to target cells or proteins. Its cleavable nature ensures controlled drug release, optimizing the effectiveness of ADCs.

(S)-TCO-PEG8-acid is a click chemistry PEG linker characterized by a terminal carboxylic acid (COOH) group. This terminal group reacts with primary amine groups to form stable amide bonds. As a PEG-based PROTAC linker, (S)-TCO-PEG8-acid is utilized in PROTAC synthesis. It is longer compared to (S)-TCO-PEG3-acid.

Tetrazine-PEG4-amine (hydrochloride) serves as a cleavable 4-unit PEG ADC linker and a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. It features a Tetrazine group capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with molecules that contain TCO groups.

Tetrazine-PEG6-amine (hydrochloride) serves as a cleavable 6-unit PEG ADC linker and a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. Featuring a Tetrazine group, it undergoes an inverse electron demand Diels-Alder reaction (iEDDA) with TCO-group-containing molecules.

Tetrazine-Ph-SS-amine, a cleavable ADC linker, facilitates the synthesis of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent features a Tetrazine group capable of engaging in an inverse electron demand Diels-Alder reaction (iEDDA) with TCO group-containing molecules.

TCO-NHS Ester axial is a click chemistry reagent and serves as a building block for amine reactions. It contains a TCO group that undergoes inverse electron demand Diels-Alder (iEDDA) reactions with molecules featuring a Tetrazine group.

Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker with a terminal methyltetrazine group, allowing it to react with TCO-containing compounds without the need for Cu-catalysis or high temperatures. It also features a terminal amine capable of specifically and efficiently reacting with NHS esters. The PEG spacer enhances water solubility.

TCO-PEG4-TFP ester is an amine-reactive labeling reagent used for the modification of proteins, antibodies, and other amine-containing biopolymers. TFP is a reactive ester that demonstrates superior stability during hydrolysis in aqueous media, enhancing the efficiency and reproducibility of biopolymer labeling. The TFP ester of carboxylic acid reacts with primary amines at a rate equivalent to NHS esters, forming a covalent amide bond identical to that produced by the reaction of primary amines with NHS or sulfo-NHS esters.

(S,E)-TCO-NHS Ester is a Click Amino Acid utilized for labeling amine-containing compounds or biomolecules. The TCO-NHS ester comprises a TCO group, which can undergo an inverse-electron-demand Diels-Alder reaction (iEDDA) with molecules possessing Tetrazine groups.