tco peg6 amine

TCO-PEG6-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tetrazine-PEG6-amine (hydrochloride) serves as a cleavable 6-unit PEG ADC linker and a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. Featuring a Tetrazine group, it undergoes an inverse electron demand Diels-Alder reaction (iEDDA) with TCO-group-containing molecules.