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Results for "
tbe31
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- Cell Research1
- TBE-31TBE 31T28929936475-62-6TBE-31 is a highly potent activator of Nrf2, a liver carcinogenesis blocker and a potent phase 2 cytoprotective pathway inducer.
- $2,420
SizeQTY - TBE56TYD-048351459836-79-3TBE56 is a molecular glue serving as a BACH1 degrader, with an EC50 of 44 nM. It is a weak NRF2 inducer and is the biotinylated form of TBE31. TBE56 interacts with BACH1 via an E3 ligase FBX022-mediated mechanism to promote its degradation. It reduces Fe2+ accumulation, ROS generation, and malondialdehyde (MDA) levels in bone marrow mesenchymal stem cells (BMSCs) overexpressing Prominin-2, while increasing the GSH/GSSG ratio and upregulating GPX4. In a puncture-induced spinal disc degeneration (IVDD) model in SD rats, TBE56 significantly improves disc degeneration, making it useful for studying IVDD.
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