stress-mediated

Expression system: E. coli
Length: 1-387, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-171, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-469, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-444, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 2-589, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-708, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-464, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-168, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-391, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-216, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-216, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 24-167, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 28-763, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 28-763, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-510, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-492, Full Length of Mature Protein
Activity: Not Tested

The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1 LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways.

Expression system: E. coli
Length: 1-646, Full Length
Activity: Not Tested

Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resistance to cellular oxidative stress. Aldehyde dehydrogenase 1A1 (ALDH1A1) and ALDH3A1 are corneal crystallins. They protect inner ocular tissues from ultraviolet radiation (UVR)-induced oxidative damage through catalytic and non-catalytic mechanisms. Additionally, ALDH3A1 has been postulated to play a regulatory role in the corneal epithelium based on several studies that report an inverse association between ALDH3A1 expression and corneal cell proliferation. Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in many cellular oxidative processes, including cancer chemoresistance, by metabolizing activated forms of oxazaphosphorine drugs such as cyclophosphamide (CP) and its analogues, such as mafosfamide (MF), ifosfamide (IFM), and 4-hydroperoxycyclophosphamide (4-HPCP). Compounds that can selectively target ALDH3A1 could permit delineation of its roles in these processes and could restore chemosensitivity in cancer cells that express this isoenzyme. ALDH3A1 may act to protect corneal cells against cellular oxidative damage by metabolizing toxic lipid peroxidation products (e.g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant.

Expression system: HEK293 Cells
Length: 1-155, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-187, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-394, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-382, Full Length
Activity: Not Tested