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Results for "
sr-0813
" in TargetMol Product Catalog- Inhibitors & Agonists1
SR-0813 
T402292597186-19-9
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL AF9, with an IC50 of 25 nM and EC50 of 205 nM for the ENL YEATS domain, and an IC50 of 311 nM and EC50 of 76 nM (CETSA) for the AF9 YEATS domain. It shows over 100-fold lower affinity for MAP3K19 (Kd = 3.5 μM) compared to ENL YEATS (Kd = 30 nM). SR-0813 can be utilized in acute leukemia research.
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